Relationships of Total and Domain-Specific Moderate-to-Vigorous Physical Activity with All-Cause and Disease-Specific Mortality.

Kikuchi H et al

Medicine & Science in Sports & Exercise 56(3):p 520-527, March 2024. |


This study aimed to investigate the relationships of moderate-to-vigorous physical activity (MVPA) with all-cause and disease-specific mortality. We also investigated how the association between MVPA at leisure time (LT-MVPA) and health outcomes differs at different MVPA at work (WT-MVPA) levels.


The 81,601 community-dwelling Japanese persons age 50–79 yr who responded to a questionnaire in 2000–2003 were followed until 2018. Cox proportional hazard model was used to examine the association of total MVPA with risks of all-cause, cancer, heart disease, stroke, and respiratory disease mortality. Then, we compared the mortality risk according to the tertile of LT-MVPA, stratified by the tertile of WT-MVPA.


During the 15.1 yr of average follow-up, 16,951 deaths were identified. Even total MVPA below the recommended volume (i.e., 0.1–1.49 MET·h·d−1) was associated with 11% to 24% reductions in all-cause (hazard ratio [HR], 0.89; 95% confidence interval [CI], 0.82–0.96) and heart disease mortality (HR, 0.76; 95% CI, 0.61–0.94), compared with no MVPA at all. The further reduced risks were seen in MVPA up to 10 MET·h·d−1. The inverse association between LT-MVPA and mortality risks was more evident at lower WT-MVPA, which was also inversely associated with the risks.


Health benefits were observed at low levels of MVPA and up to 10 MET·h·d−1, although the fine threshold for excessive MVPA was not clear. LT-MVPA had distinct health benefits especially for persons with lower WT-MVPA.